He married Mary Hinds on January 19, 1774. Mary was born on September 25, 1752 in Greenwich. She was the daughter of of Nehemiah and Sarah Hinds. Thomas' sister Susannah Powers married Mary's brother, Captain Joseph Hinds.
Their children included:
Thomas Powers (1774-1824, married Susan Converse),
Mary (Polly) Powers (1775-1849),
Warren Powers (1777),
Sally Powers Hepburn (1779),
Ezra Powers (1780),
Eunice Powers Walker (1781-1828, married William Walker),
Erastus Powers (1784),
Belara Powers Wardwell (1785, married Stephen Wardwell),
Captain Joseph Powers (1786-1853),
Anna Powers Newcomb (1788, married Calvin Newcomb), and
James Powers (1789).